肠道病毒71型疫苗质量控制研究进展

被引：14

作者：

王一平

姚昕

毛群颖

梁争论

机构：

[1] 中国食品药品检定研究院

来源：

微生物学免疫学进展 | 2015年 / 43卷 / 05期

关键词：

手足口病; 肠道病毒71型; 疫苗; 抗原; 标准品;

D O I：

10.13309/j.cnki.pmi.2015.05.016

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

手足口病(Hand foot and mouth disease,HFMD)已成为西太平洋区严重的公共卫生问题之一,肠道病毒71型(Enterovirus 71,EV71)是引起HFMD的主要病原体,研发疫苗是控制HFMD流行的有效手段。目前世界范围已有5个EV71全病毒灭活疫苗进入临床试验,其中中国研制的3种EV71疫苗已分别完成III期临床试验,结果表明3种疫苗都具有良好的安全性和保护效果。在EV71疫苗研发中,抗原质控的方法和标准是研发的瓶颈,其中抗原活性测定是工序工艺优化、免疫原性评价和剂量确定的关键指标。综述了EV71疫苗抗原质控的研究进展。

引用

页码：69 / 72

页数：4

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