迷走神经在心律失常发生中的研究进展

被引：8

作者：

冯璇

臧伟进

周筠

机构：

[1] 西安交通大学医学院药理学系

来源：

心脏杂志 | 2012年 / 24卷 / 05期

关键词：

长QT综合征; 迷走神经; 心律失常;

D O I：

10.13191/j.chj.2012.05.104.fengx.019

中图分类号：

R541.7 [心律失常];

学科分类号：

100201 [内科学];

摘要：

作为遗传性心律失常之一的长QT综合征(LQTS),现已发现有12型,其中在中国以LQT2为常见,可诱发尖端扭转型室性心动过速及室颤,临床上以反复发作的晕厥及常导致的猝死为特征。自主神经通过释放神经递质作用于受体调节离子通道,从而对某些心律失常起到一定的作用,而迷走神经通过直接或间接作用对多种心律失常具有一定的保护作用。本文主要对LQT2的研究进展、迷走神经与LQT2的关系以及其在心律失常中发挥的作用作一综述。

引用

页码：646 / 650

页数：5

共 8 条

[1]

Increased susceptibility to ischemia-induced ventricular tachyarrhythmias in depressed rats: Involvement of reduction of connexin 43 [J].

Wu, Wei ;

Li, Yan ;

Lu, Zhibing ;

Hu, Xiaorong .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2012, 3 (02) :192-194

[2]

Connexin Gene Transfer Preserves Conduction Velocity and Prevents Atrial Fibrillation [J].

Igarashi, Tomonori ;

Finet, J. Emanuel ;

Takeuchi, Ayano ;

Fujino, Yoshihisa ;

Strom, Maria ;

Greener, Ian D. ;

Rosenbaum, David S. ;

Donahue, J. Kevin .

CIRCULATION, 2012, 125 (02) :216-U103

[3]

Prevention and Reversal of Atrial Fibrillation Inducibility and Autonomic Remodeling by Low-Level Vagosympathetic Nerve Stimulation [J].

Sheng, Xia ;

Scherlag, Benjamin J. ;

Yu, Lilei ;

Li, Shuyan ;

Ali, Reza ;

Zhang, Ying ;

Fu, Guosheng ;

Nakagawa, Hiroshi ;

Jackman, Warren M. ;

Lazzara, Ralph ;

Po, Sunny S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (05) :563-571

[4]

Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells [J].

van Borren, Marcel M. G. J. ;

Verkerk, Arie O. ;

Wilders, Ronald ;

Hajji, Najat ;

Zegers, Jan G. ;

Bourier, Jan ;

Tan, Hanno L. ;

Verheijck, Etienne E. ;

Peters, Stephan L. M. ;

Alewijnse, Astrid E. ;

Ravesloot, Jan-Hindrik .

BASIC RESEARCH IN CARDIOLOGY, 2010, 105 (01) :73-87

[5]

Pharmacological Enhancement of Cardiac Gap Junction Coupling Prevents Arrhythmias in Canine LQT2 Model [J].

Quan, Xiao-Qing ;

Bai, Rong ;

Lu, Jia-Gao ;

Patel, Chinmay ;

Liu, Nian ;

Ruan, Yanfei ;

Chen, Bo-Di ;

Ruan, Lei ;

Zhang, Cun-Tai .

CELL COMMUNICATION AND ADHESION, 2009, 16 (1-3) :29-38

[6]

Rapid component I Kr of cardiac delayed rectifier potassium currents in guinea-pig is inhibited by α 1 -adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways.[J].Sen Wang;Dong-Jie Xu;Jing-bo Cai;Yuan-zhu Huang;Jian-Gang Zou;Ke-Jiang Cao.European Journal of Pharmacology.2009, 1

[7]

LQT2相关hERG基因的功能和表达 [J].

范丹丹 ;

周筠 .

心脏杂志, 2012, 24 (03) :402-406+410

[8]

先天性长QT综合征的新进展 [J].

胡丹 ;

阮磊 ;

张存泰 ;

白融 ;

Hector MBarajasMartinez ;

Charles Antzelevitch .

中国心脏起搏与心电生理杂志, 2011, 25 (05) :377-381

← 1 →