细胞因子对类风湿性关节炎骨平衡的调节作用

被引：24

作者：

杨林 ^{[1
]}

吕丹 ^{[1
]}

沈小芳 ^{[1
]}

张安兵 ^{[2
]}

肖娟 ^{[1
]}

机构：

[1] 湖北文理学院分子医学实验室

[2] 湖北文理学院附属襄阳市中心医院风湿免疫科

来源：

生命科学 | 2019年 / 31卷 / 01期

关键词：

类风湿性关节炎; 细胞因子; 骨损害;

D O I：

10.13376/j.cbls/2019005

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

类风湿性关节炎(rheumatoid arthritis, RA)是一种以滑膜持续炎症和关节软骨及骨质破坏为特征的自身免疫性疾病。RA的发展伴随着滑膜细胞增生、新生血管、局部大量炎性细胞浸润及细胞因子水平的失调。异常炎症反应贯穿RA始终,细胞因子失调引起的骨破坏和骨建之间的失衡导致RA关节炎症和骨质破坏。RA致残率极高,且没有根治方法对其进行早期诊断和治疗,延缓骨损伤尤为重要。目前临床常用的诊断指标缺乏特异性。现以细胞因子为切入点,概述其在RA不同时期的不同存在及对RA骨平衡的调控作用机制,为寻找RA更加精准的早期诊断指标和治疗靶点提供线索。

引用

页码：35 / 43

页数：9

共 14 条

[1]

Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity.[J].Mahmood Ahmad Khan;Mohd Jahir Khan.Artificial Cells; Nanomedicine; and Biotechnology.2018, sup1

[2]

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update [J].

Smolen, Josef S. ;

Landewe, Robert ;

Bijlsma, Johannes ;

Burmester, Gerd ;

Chatzidionysiou, Katerina ;

Dougados, Maxime ;

Nam, Jackie ;

Ramiro, Sofia ;

Voshaar, Marieke ;

van Vollenhoven, Ronald ;

Aletaha, Daniel ;

Aringer, Martin ;

Boers, Maarten ;

Buckley, Chris D. ;

Buttgereit, Frank ;

Bykerk, Vivian ;

Cardiel, Mario ;

Combe, Bernard ;

Cutolo, Maurizio ;

van Eijk-Hustings, Yvonne ;

Emery, Paul ;

Finckh, Axel ;

Gabay, Cem ;

Gomez-Reino, Juan ;

Gossec, Laure ;

Gottenberg, Jacques-Eric ;

Hazes, Johanna M. W. ;

Huizinga, Tom ;

Jani, Meghna ;

Karateev, Dmitry ;

Kouloumas, Marios ;

Kvien, Tore ;

Li, Zhanguo ;

Mariette, Xavier ;

McInnes, Iain ;

Mysler, Eduardo ;

Nash, Peter ;

Pavelka, Karel ;

Poor, Gyula ;

Richez, Christophe ;

van Riel, Piet ;

Rubbert-Roth, Andrea ;

Saag, Kenneth ;

da Silva, Jose ;

Stamm, Tanja ;

Takeuchi, Tsutomu ;

Westhovens, Rene ;

de Wit, Maarten ;

van der Heijde, Desiree .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (06) :960-977

[3]

A randomised phase IIb study of mavrilimumab; a novel GM–CSF receptor alpha monoclonal antibody; in the treatment of rheumatoid arthritis.[J].Gerd R Burmester;Iain B McInnes;Joel Kremer;Pedro Miranda;Mariusz Korkosz;Jiri Vencovsky;Andrea Rubbert-Roth;Eduardo Mysler;Matthew A Sleeman;Alex Godwood;Dominic Sinibaldi;Xiang Guo;Wendy I White;Bing Wang;Chi-Yuan Wu;Patricia C Ryan;David Close;Michael E Weinblatt.Annals of the Rheumatic Diseases.2017, 6

[4]

A randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate [J].

Smolen, Josef S. ;

Agarwal, Sandeep K. ;

Ilivanova, Elena ;

Xu, Xie Lillian ;

Miao, Ye ;

Zhuang, Yanli ;

Nnane, Ivo ;

Radziszewski, Waldemar ;

Greenspan, Andrew ;

Beutler, Anna ;

Baker, Daniel .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (05) :831-839

[5]

Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF- β 1 by Regulatory T Cells.[J].Huihui Xu;Hongyan Zhao;Cheng Lu;Qi Qiu;Gui Wang;Jing Huang;Minghui Guo;Baosheng Guo;Yong Tan;Cheng Xiao;Marije I. Koenders.Mediators of Inflammation.2016,

[6]

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161<sup>+</sup>Th1 Cells) to CD161<sup>+</sup>Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients.[J].Shigeru Kotake;Yuki Nanke;Toru Yago;Manabu Kawamoto;Tsuyoshi Kobashigawa;Hisashi Yamanaka;Anil K. Singh.BioMed Research International.2016,

[7]

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies [J].

Cavalli, Giulio ;

Dinarello, Charles A. .

RHEUMATOLOGY, 2015, 54 (12) :2134-2144

[8]

The roles of interferons in osteoclasts and osteoclastogenesis [J].

Xiong, Qi ;

Zhang, Lihai ;

Ge, Wei ;

Tang, Peifu .

JOINT BONE SPINE, 2016, 83 (03) :276-281

[9]

The Role of IL-1 β in the Bone Loss during Rheumatic Diseases.[J].Piero Ruscitti;Paola Cipriani;Francesco Carubbi;Vasiliki Liakouli;Francesca Zazzeroni;Paola Di Benedetto;Onorina Berardicurti;Edoardo Alesse;Roberto Giacomelli;Nina Ivanovska.Mediators of Inflammation.2015,

[10]

ACPA and Bone Loss in Rheumatoid Arthritis [J].

Kocijan, Roland ;

Harre, Ulrike ;

Schett, Georg .

CURRENT RHEUMATOLOGY REPORTS, 2013, 15 (10)

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