药物性肝损伤的流行病学

被引:38
作者
沈弢
段昭君
庄辉
机构
[1] 北京大学医学部基础医学院病原生物学系
关键词
D O I
10.14000/j.cnki.issn.1008-1704.2015.10.018
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
<正>一、药物性肝损伤概念和分类药物性肝损伤(DILI)是指人体暴露于常规剂量或高剂量药物后,因药物本身或其代谢产物对肝脏的直接毒性,或人体对药物或其代谢产物产生过敏或代谢特异质反应而导致的肝脏损伤[1]。DILI通常分为两类,特异质型肝损伤和固有型肝损伤[1]。前者主要为人体对药物或其代谢产物产生过敏或代谢特异质反应,具有不可预测性,潜伏期较长或不确定,剂量依赖性较
引用
收藏
页码:819 / 823
页数:5
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