高迁移率族蛋白B1与脑缺血

被引:3
作者
殷益宏
任明山
机构
[1] 安徽医科大学附属省立医院神经内科
关键词
HMGB1蛋白质; 炎症; 脑缺血; 细胞凋亡;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
高迁移率族蛋白B1(high mobility group box 1,HMGB1)是高迁移率族蛋白家族成员之一。细胞外HMGB1和细胞表面受体——晚期糖基化终产物受体(receptor for advanced glycationendproduct,RAGE)、Toll样受体2(toll like receptor 2,TLR2)和Toll样受体4(toll like receptor 4,TLR4)结合,与其他促炎介质协同作用,促进炎症级联反应。脑缺血后,过度表达的HMGB1参与了炎症反应、神经元凋亡等病理生理学过程。
引用
收藏
页码:228 / 230
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