抗抑郁新药——瑞美隆

被引：3

作者：

毛叶萌

笪志民

机构：

[1] 上海市精神卫生中心

[2] 上海市精神卫生中心上海

[3] 上海

来源：

上海医药 | 1998年 / 06期

关键词：

瑞美隆; 抑郁症; 安慰剂; 重症抑郁; 药理机制; 忧郁症; 情感性精神病; 空白剂; 阿米替林;

D O I：

暂无

中图分类号：

R971 [神经系统药物];

学科分类号：

摘要：

<正> 瑞美隆（Remeron）的国际通用名是米他扎品（Mirtazapine）.其药理机制与以往的各类抗抑郁药不同,被称为Nassa（Noradrenergic and Specific Serotonergic Antidepressants,去甲肾上腺素和特异的五羟色胺抗抑郁药）。本文就该药的药理特性、临床疗效及不良反应作一概述。 1 药理特性 1.1 作用机制瑞美隆的作用机制与以前我们所知的任何一种抗抑郁药均不相同,它同时作用于去甲肾上腺素神经和5-HT神经,促使去甲肾上腺素（NA）和5-HT的神经传导,起抗抑郁作用。神经生理学研究表明,瑞美隆通过三种途径起抗抑郁作用:（1）作用于脑去甲肾上腺素突触前膜α1自身受体,增加去甲肾上腺素神经冲动发放,促使NA释放,起部分抗抑郁作用。（2）5-HT神经冲动发放受5-HT神经细胞上的

引用

页码：31 / 32

页数：2

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