奥拉西坦的临床前药理学研究

被引:30
作者
金磊 [1 ]
李博 [2 ]
叶雷 [3 ]
蔡云红 [3 ]
荣祖元 [1 ]
机构
[1] 四川抗菌素工业研究所药理部
[2] 第三军医大学西南医院神经外科
[3] 重庆东泽医药科技发展有限公司
关键词
奥拉西坦; 促智药; 认知增强剂; 学习记忆; 神经保护;
D O I
暂无
中图分类号
R961 [药物的性质和作用];
学科分类号
100602 ; 100706 ;
摘要
促智药奥拉西坦的问世已有二十余年,国内外对其药理学特征进行了广泛而深入的研究。作为一个在一般药理学上无活性、无毒的认知增强剂,它具备良好的药代动力学特性,其药理作用包括对学习记忆的改善作用以及一定的神经保护作用,其作用机制可能涉及:对中枢胆碱能系统的作用以及其它与认知相关的递质系统(如谷氨酸系统、单胺递质系统)与胆碱能系统的相互作用;对长时程增强的诱导和维持作用;对蛋白激酶C的激活作用;对脑代谢的改善作用;以及外周类固醇激素的影响等。
引用
收藏
页码:354 / 360
页数:7
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