Wnt信号通路与骨髓间充质干细胞成骨之间的关系

被引：8

作者：

王丽雅

廖学娟

郑晓辉

龙洁

机构：

[1] 四川大学华西口腔医院口腔颌面外科

来源：

现代生物医学进展 | 2012年 / 12卷 / 20期

关键词：

骨髓间充质干细胞; Wnt信号通路; 骨向分化;

D O I：

10.13241/j.cnki.pmb.2012.20.017

中图分类号：

R329 [人体组织学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

Wnt信号通路是由Wnts诱发的一系列相互作用的分子组成。Wnt信号对骨髓间充质干细胞的影响在所有研究中均证实有明显作用,其可调节干细胞增殖、分化及凋亡。研究表明,抑制Wnt信号通路转导可使成骨细胞分化进程受阻,从而抑制骨形成;若诱导Wnt家族成员表达则可使成骨细胞特异性基因表达增加,促进骨形成。本文就Wnt信号通路的作用过程及其与骨髓间充质干细胞成骨诱导的关系做一综述。

引用

页码：3981 / 3984

页数：4

共 12 条

[1]

Noncanonical Wnt Signaling Orchestrates Early Developmental Events toward Hematopoietic Cell Fate from Human Embryonic Stem Cells [J].

Vijayaragavan, Kausalia ;

Szabo, Eva ;

Bosse, Marc ;

Ramos-Mejia, Veronica ;

Moon, Randall T. ;

Bhatia, Mickie .

CELL STEM CELL, 2009, 4 (03) :248-262

[2]

Selective activation mechanisms of Wnt signaling pathways [J].

Kikuchi, Akira ;

Yamamoto, Hideki ;

Sato, Akira .

TRENDS IN CELL BIOLOGY, 2009, 19 (03) :119-129

[3]

Planar Cell Polarity Signaling: From Fly Development to Human Disease.[J].Matias Simons;Marek Mlodzik.Annual Review of Genetics.2008, 0

[4]

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation [J].

Kahler, Rachel A. ;

Yingst, Sorcha M. C. ;

Hoeppner, Luke H. ;

Jensen, Eric D. ;

Krawczak, David ;

Oxford, Julia T. ;

Westendorf, Jennifer J. .

MATRIX BIOLOGY, 2008, 27 (04) :330-338

[5]

Cross-talk of WNT and FGF signaling pathways at GSK3? to regulate ?-catenin and SNAIL signaling cascades.[J].Masuko Katoh;Masaru Katoh.Cancer Biology & Therapy.2006, 9

[6]

Interaction of nuclear receptors with the Wnt/β-catenin/Tcf signaling axis:: Wnt you like to know? [J].

Mulholland, DJ ;

Dedhar, S ;

Coetzee, GA ;

Nelson, CC .

ENDOCRINE REVIEWS, 2005, 26 (07) :898-915

[7]

Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells.[J].Amanda Jackson;Béatrice Vayssière;Teresa Garcia;William Newell;Roland Baron;Sergio Roman-Roman;Georges Rawadi.Bone.2005, 4

[8]

WNT/PCP signaling pathway and human cancer (review) [J].