基于网络药理学的葛根抗肿瘤潜在机制探讨

被引：19

作者：

张莉华 ^{[1
]}

崔明超 ^{[2
]}

陈少军 ^{[2
]}

机构：

[1] 浙江医药高等专科学校食品学院

[2] 浙江医药高等专科学校中药学院

来源：

天然产物研究与开发 | 2018年 / 30卷 / 04期

关键词：

葛根; 网络药理学; 肿瘤; 靶点; 作用机制;

D O I：

10.16333/j.1001-6880.2018.4.003

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

本文采用网络药理学方法探讨葛根的抗肿瘤的作用机制。首先采用类药性评估筛选葛根的活性成分,然后反向分子对接法预测作用靶点,在pubmed数据库人工检索靶点是否与肿瘤相关。靶点信息导入到生物注释系统MAS3.0,结合KEGG数据库进行靶点分析和通路分析,cytoscape软件中分别绘制化合物-靶点、靶点-通路网络,最后合并生成成分-靶点-作用网络图。实验结果显示从葛根中筛选出16个活性化合物,并预测出34个靶蛋白和44条信号通路。网络分析发现葛根潜在作用通路有直接作用于多种肿瘤疾病,也有间接作用于多条与肿瘤形成发展有关的通路。综上,葛根通过多成分、多靶点、多通路的形式发挥着抗肿瘤作用,为后续作用药理实验提供了依据,也为其他中药的相关研究提供借鉴和参考。

引用

页码：547 / 553+615 +615

页数：8

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