D-Limonene对小鼠移植瘤生长及淋巴管生成的影响

被引:4
作者
杨慧科
李玉兰
刘慧冬
李晓冬
杨树才
龚春琳
赵玲辉
机构
[1] 哈尔滨医科大学基础医学院解剖教研室
基金
黑龙江省自然科学基金;
关键词
右旋柠烯; 移植瘤; 淋巴管生成; LYVE-1;
D O I
10.13418/j.issn.1001-165x.2007.01.022
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 ;
摘要
目的:观察右旋柠烯对小鼠移植瘤生长及淋巴管生成的影响,并探讨其作用机制。方法:皮下注射肉瘤(S180)腹水型瘤株构建小鼠移植瘤模型,给予D-Lim onene干预,免疫组化染色观察瘤细胞V EG F-C表达,LY V E-1标记淋巴管,观察其分布。结果:对照组瘤细胞V EG F-C表达较强,瘤周边部淋巴管较多,有淋巴结、肺转移。用药组瘤细胞V EG F-C表达较弱;瘤周边部淋巴管较少,未见淋巴结、肺转移。结论:D-Lim onene有抑制移植瘤内瘤细胞V EG F-C表达和淋巴管生成的作用,有可能降低肿瘤的淋巴道转移。
引用
收藏
页码:57 / 59
页数:3
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