血管紧张素-(1-7)在动脉粥样硬化中的作用

被引：5

作者：

张锋 ^{[1
,2
]}

任景怡 ^{[1
]}

陈红 ^{[1
]}

机构：

[1] 北京大学人民医院心内科

[2] 伦敦大学国王学院心血管研究中心

来源：

中国生物化学与分子生物学报 | 2013年 / 29卷 / 01期

关键词：

动脉粥样硬化; 血管紧张素-(1-7); 平滑肌细胞增殖及迁移; 内皮细胞功能; 脂质代谢;

D O I：

10.13865/j.cnki.cjbmb.2013.01.001

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

血管紧张素-(1-7)[angiotensin-(1-7),Ang-(1-7)]是肾素-血管紧张素系统(renin-angiotensin system,RAS)的新成员之一.与血管紧张素Ⅱ(AngⅡ)比较,Ang-(1-7)在高血压及动脉粥样硬化等疾病中发挥着心血管保护作用.最新研究发现,Ang-(1-7)在平滑肌细胞增殖及迁移、内皮细胞功能、脂质代谢的这些动脉粥样硬化相关病理发展过程中起着重要作用,能够抑制动脉粥样硬化斑块的形成及加强斑块的稳定性.本文就Ang-(1-7)与动脉粥样硬化疾病相关的最新研究进展进行综述,讨论Ang-(1-7)在动脉粥样硬化中的作用机制,也为Ang-(1-7)相关的ACE2/Ang-(1-7)/Mas轴作为未来临床治疗途径提供思路.

引用

页码：1 / 6

页数：6

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