ConA激活的小鼠T细胞CD69表达动力学的体内外研究

被引:6
作者
张雷
葛琪
孙尔维
曾耀英
闵志廉
机构
[1] 上海长征医院泌尿外科!上海
[2] 暨南大学组织移植与免疫国家专业实验室!广东广州
[3] 广州珠江医院肾移植科!广东广州
关键词
T细胞活化; CD69; 动力学;
D O I
10.13431/j.cnki.immunol.j.20000066
中图分类号
R392.12 [免疫细胞生物学];
学科分类号
摘要
目的为明确 CD6 9体内外表达动力学并进一步探讨其作用。方法 Con A体内外刺激小鼠 T细胞后 ,选取不同时间点 ,流式细胞仪观察 T细胞 CD6 9表达率。结果 Con A刺激后 2 h CD6 9即有明显表达 ,6~ 8h达到峰值 ;CD8-与 CD8+T细胞相比无明显差异 ;体外条件对 CD6 9的表达有显著的影响。结论结果提示 CD8-和 CD8+T细胞的活化均需要 CD6 9的参与 ;T细胞可能在活化早期一过性高表达 CD6 9;CD6 9很可能是一个 T细胞增殖的共刺激信号
引用
收藏
页码:210 / 213
页数:4
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