高迁移率族蛋白B1:自身免疫性疾病重要炎性分子

被引:4
作者
潘舒月
青玉凤
周京国
机构
[1] 川北医学院附属医院风湿免疫科
关键词
高迁移率族蛋白B1; 自身免疫性疾病; 系统性红斑狼疮; 关节炎; 干燥综合征; 肌炎;
D O I
暂无
中图分类号
R593.2 [自身免疫性疾病、结缔组织疾病];
学科分类号
1002 ; 100201 ;
摘要
高迁移率族蛋白B1(High mobility group box 1 protein,HMGB1)是一种核内非组蛋白,其可在免疫激活和细胞死亡等过程中发生转录后修饰并转移到细胞外参与炎性反应。HMGB1的活性可随其半胱氨基酸残基的氧化还原状态而变化。HMGB1可以通过直接刺激细胞分泌炎性因子,也可与其他细胞因子结合形成免疫复合体后,作为一种配体与相应受体结合传递信号参与炎性反应。HMGB1能作为一种警报素预警炎性反应,并参与自身免疫性疾病的发病过程。
引用
收藏
页码:198 / 202
页数:5
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