普罗托品对家兔血小板功能的影响

被引：14

作者：

马国义

张子昭

陈植和

机构：

[1] 昆明医学院药理教研室

[2] 昆明医学院药理教研室昆明中国

[3] 昆明中国

[4] 昆明

来源：

Acta Pharmacologica Sinica | 1994年 / 04期

关键词：

普罗托品; 血小板聚集; 血栓素A2; 环腺苷-磷酸; 环鸟苷-磷酸; 腺苷二磷酸; 花生四烯酸; 胶原; 蛇毒;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

普罗托品（protopine,Pro）体外(1—1000μmol·L-1)和体内(10和20mg·kg-1)均抑制ADP,胶原,花生四烯酸（AA）和烙铁头蛇毒血小板聚集素（TMVA）诱导的兔血小板聚集及血小板5-HT释放。Pro不抑制AA诱导的免血小板TXA2生成。也不升高血小板内cAMP水平,但升高cGMP水平。提示其抗血小板作用的机制与升高血小板内cGMP水平,抑制血小板释放活性物质有关。

引用

页码：81 / 85

页数：5

共 7 条

[1]

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[2]

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[3]

Roth P, Weber PC.Stimulated platelet aggre gation, thromboxane B2 formation and platelet sensitivity ??to prostacyclin-A critical evaluation. Siess W. Thrombosis and Haemostasis . 1981

[4]

Platetets and prostaglandins in coronary artery disease.Rationale for use of platelet-suppressive drugs. Mehta J. The Journal of The American Medical Association . 1983

[5]

The activation of human platelets induced by the aggregoserpentin of Trimeresurus mucrosquamatus venom (TMVA). Chen H,Wan HY,Ruan CG. Zoological Research . 1987

[6]

Aggregation of blood platelets by adenosine diphosphate and its reversal. Born GVR. Nature . 1962

[7]

Analgesic and antispastic effects of protopine. Yue KL. Acta Pharmacological Sinica . 1981

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