老年抑郁症患者认知功能损害与血清皮质醇的关系研究

被引：12

作者：

钟笑梅

吴章英

王艳华

陈贲

彭琪

陈辛茹

张蔚茹

欧阳聪

胡国艳

林裕龙

陈建平

李含秋

施海姗

宁玉萍

机构：

[1] 广州医科大学附属脑科医院广州市惠爱医院

来源：

四川精神卫生 | 2016年 / 29卷 / 02期

基金：

广州市科技计划项目;

关键词：

老年抑郁症; 认知损害; 发作期; 恢复期; 皮质醇;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的探讨老年抑郁症(LLD)患者认知功能损害与血清皮质醇水平的关系。方法纳入LLD认知损害患者35例、LLD认知正常患者14例、正常对照组25例,采用汉密尔顿抑郁量表17项版(HAMD-17)和简易智能状态评价量表(MMSE)分别评定抑郁症状和总体认知功能,采用化学发光微粒子免疫法测定血清皮质醇浓度。结果 LLD认知损害患者的血清皮质醇水平高于LLD认知正常者[(11.83±4.70)ug/d Lvs.(8.21±3.64)ug/d L,P<0.01]。LLD发作期伴认知损害者[(11.6±4.6)ug/d L]、LLD恢复期伴认知损害者[(12.4±5.2)ug/d L]血清皮质醇水平均高于LLD恢复期认知正常者[(8.5±3.7)ug/d L]及正常对照组[(8.6±4.3)ug/d L](P均<0.05)。结论伴有认知损害的LLD患者,无论是处于发作期还是恢复期,血清皮质醇水平均升高。皮质醇水平可能是影响LLD患者认知功能的重要因素。

引用

页码：123 / 127

页数：5

共 13 条

[1]

Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: A longitudinal study.[J].Breno Satler Diniz;Charles F. Reynolds;Amy Begley;Mary Amanda Dew;Stewart J. Anderson;Francis Lotrich;Kirk I. Erickson;Oscar Lopez;Howard Aizenstein;Etienne L. Sibille;Meryl A. Butters.Journal of Psychiatric Research.2014,

[2]

HPA axis and aging in depression: Systematic review and meta-analysis.[J].Martino Belvederi Murri;Carmine Pariante;Valeria Mondelli;Mattia Masotti;Anna Rita Atti;Zefiro Mellacqua;Marco Antonioli;Lucio Ghio;Marco Menchetti;Stamatula Zanetidou;Marco Innamorati;Mario Amore.Psychoneuroendocrinology.2014,

[3]

The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features [J].

Naismith, Sharon L. ;

Norrie, Louisa M. ;

Mowszowski, Loren ;

Hickie, Ian B. .

PROGRESS IN NEUROBIOLOGY, 2012, 98 (01) :99-143

[4]

Subtypes of Mild Cognitive Impairment Among the Elderly With Major Depressive Disorder in Remission [J].

Yeh, Yi-Chun ;

Tsang, Hin-Yeung ;

Lin, Pao-Yen ;

Kuo, Yu-Ting ;

Yen, Cheng-Fang ;

Chen, Cheng-Chung ;

Liu, Gin-Chung ;

Chen, Cheng-Sheng .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2011, 19 (11) :923-931

[5]

Depression in Older Adults.[J].Amy Fiske;Julie Loebach Wetherell;Margaret Gatz.Annual Review of Clinical Psychology.2009, 1

[6]

Persistence of neuropsychologic deficits in the remitted state of late-life depression [J].

Bhalla, RK ;

Butters, MA ;

Mulsant, BH ;

Begley, AE ;

Zmuda, MD ;

Schoderbek, B ;

Pollock, BG ;

Reynolds, CF ;

Becker, JT .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2006, 14 (05) :419-427

[7]

Glucocorticoids and Relapse of Major Depression (Dexamethasone/Corticotropin-Releasing Hormone Test in Relation to Relapse of Major Depression).[J].Bente C. Appelhof;Jochanan Huyser;Mijke Verweij;Jantien P. Brouwer;Richard van Dyck;Eric Fliers;Witte J.G. Hoogendijk;Jan G.P. Tijssen;Wilmar M. Wiersinga;Aart H. Schene.Biological Psychiatry.2005, 8

[8]

Six-month course of mild cognitive impairment and affective symptoms in late-life depression [J].