整合素及其调控破骨细胞相关信号机制研究进展

被引：11

作者：

仝锡帅

顾建红

刘宗平

机构：

[1] 扬州大学兽医学院

来源：

动物医学进展 | 2013年 / 34卷 / 05期

关键词：

整合素; 破骨细胞; 信号转导;

D O I：

10.16437/j.cnki.1007-5038.2013.05.020

中图分类号：

S852.2 [家畜生理学、生物物理学、生物化学];

学科分类号：

090507 [智慧养殖与动物生产学];

摘要：

整合素是一类细胞膜表面跨膜蛋白,在介导细胞黏附并参与细胞内外信号传递的过程中具有重要意义。破骨细胞在骨重建与骨吸收的动态平衡中起关键调控作用,尤其是封闭带中的整合素αvβ3是影响骨吸收的主要黏附分子,对破骨细胞内外Ca2+及下游信号的调控起关键作用。论文对整合素的结构、分类、功能及其调控破骨细胞相关信号的机制进行了阐述。

引用

页码：99 / 102

页数：4

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