降钙素原在全身性感染诊治中的研究进展

被引:82
作者
石岩
刘大为
机构
[1] 中国医学科学院北京协和医学院北京协和医院ICU
关键词
D O I
暂无
中图分类号
R515 [细菌传染病、球菌传染病];
学科分类号
摘要
<正>随着临床对感染诊断客观指标需求的日益迫切,近年来涌现出了各种标记物,其中应用最为广泛的当属降钙素原(procalcitonin,PCT),其经历了观察性、荟萃分析及大规模随机对照研究3个阶段。以下对PCT的特性及其在全身性感染诊治中的作用做一综述。一、PCT的生物学特性PCT是1992年发现的人类降钙素前肽,是一种无激素活性的糖蛋白,含116个氨基酸,相对分子质量约13 000,其
引用
收藏
相关论文
共 12 条
  • [1] 可溶性髓样细胞触发性受体1对感染性疾病的诊断价值
    杨朴强
    顾勤
    刘宁
    虞竹溪
    [J]. 中国呼吸与危重监护杂志, 2010, 9 (02) : 213 - 215
  • [2] 血清降钙素原与感染性疾病并全身炎性反应综合征的相关性研究
    汪明明
    孙玉秋
    张娟
    崔速南
    史兆章
    张景遥
    [J]. 中华内科杂志, 2002, (10) : 45 - 46
  • [3] Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial[J] . The Lancet . 2010 (9713)
  • [4] Procalcitonin ratio indicates successful surgical treatment of abdominal sepsis
    Novotny, Alexander R.
    Emmanuel, Klaus
    Hueser, Norbert
    Knebel, Carolin
    Kriner, Monika
    Ulm, Kurt
    Bartels, Holger
    Ruediger, Joerg
    Holzmann, Bernhard
    [J]. SURGERY, 2009, 145 (01) : 20 - 26
  • [5] Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study[J] . Shigeatsu Endo,Naoki Aikawa,Seitaro Fujishima,Isao Sekine,Kazuhiro Kogawa,Yasuhiro Yamamoto,Shigeki Kushimoto,Hidekazu Yukioka,Noboru Kato,Kyoichi Totsuka,Ken Kikuchi,Toshiaki Ikeda,Kazumi Ikeda,Hiroyuki Yamada,Kazuaki Harada,Shinji Satomura.Journal of Infection and Chemotherapy . 2008 (3)
  • [6] Diagnosis of ventilator-associated pneumonia: is there a gold standard and a simple approach?[J] . Thiago Lisboa,Jordi Rello.Current Opinion in Infectious Diseases . 2008 (2)
  • [7] The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
    de Kruif, Martijn D.
    Lemaire, Lucienne C.
    Giebelen, Ida A.
    Struck, Joachim
    Morgenthaler, Nils G.
    Papassotiriou, Jana
    Elliott, Peter J.
    van der Poll, Tom
    [J]. INTENSIVE CARE MEDICINE, 2008, 34 (03) : 518 - 522
  • [8] Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis[J] . Benjamin MP Tang,Guy D Eslick,Jonathan C Craig,Anthony S McLean.The Lancet Infectious Diseases . 2007 (3)
  • [9] Prognosis of community acquired pneumonia (CAP): Value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response[J] . Alicia Tejera,Francisco Santolaria,María-Luisa Diez,María-Remedios Alemán-Valls,Emilio González-Reimers,Antonio Martínez-Riera,Antonio Milena-Abril.Cytokine . 2007 (3)
  • [10] Procalcitonin increase in early identification of critically ill patients at high risk of mortality
    Jensen, Jens Ulrik
    Heslet, Lars
    Jensen, Tom Hartvig
    Espersen, Kurt
    Steffensen, Peter
    Tvede, Michael
    [J]. CRITICAL CARE MEDICINE, 2006, 34 (10) : 2596 - 2602