JWA基因-76G>C和454C>A多态性与宫颈癌易感性

被引：3

作者：

朱慧 ^{[1
]}

王美林 ^{[2
]}

李春平 ^{[2
]}

李爱萍 ^{[2
]}

沈洪兵 ^{[2
]}

韩素萍 ^{[1
]}

机构：

[1] 南京医科大学第一附属医院妇产科

[2] 南京医科大学公共卫生学院分子毒理学实验室

来源：

南京医科大学学报(自然科学版) | 2008年 / 04期

关键词：

JWA基因; 宫颈癌; 基因多态性; 分子流行病学;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

摘要：

目的:探讨JWA基因多态性与江苏人群宫颈癌易感性之间的关系。方法:采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法,检测227例宫颈癌患者和333例年龄、性别相匹配的非肿瘤者JWA-76G>C、454C>A和723T>G多态性的频率和分布,比较不同基因型携带者患宫颈癌的危险性,通过分层分析探讨初潮年龄、初次生育年龄和产次对患宫颈癌的影响。结果:JWA-76GC和454AA基因型均可增加罹患宫颈癌的危险性。携带3～5个危险等位基因者比携带0～2个等位基因者患宫颈癌的危险性更大(OR=1.70,95%CI=1.20～2.42)。分层分析结果显示,初潮年龄早、生育年龄晚和产次多且携带3～5危险等位基因者能增加患宫颈癌的危险性。本研究未发现JWA基因723T>G多态性与宫颈癌之间存在显著相关。结论:JWA基因-76G>C和454C>A多态性显著增加江苏地区汉族人群患宫颈癌的危险性。

引用

页码：462 / 466

页数：5

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