α-synuclein与帕金森病

被引：3

作者：

赵大龙

王珂

机构：

[1] 国家新药开发工程技术研究中心

来源：

中国医药生物技术 | 2010年 / 5卷 / 04期

关键词：

多巴胺能神经元损伤; 神经元; 神经组织; 帕金森病; synuclein; 蛋白聚集; 神经细胞; 中脑; 黑质; 突触囊泡; MPTP; 路易小体; 野生型; 神经变性性疾病; 基底神经节; 纹状体; 突变体; 突变型; 酪氨酸羟化酶;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

摘要：

<正>帕金森病(Parkinson's disease,PD)是一种常见的神经变性性疾病,由Parkinson于1817年首次提出,其突出表现为选择性中脑黑质多巴胺能神经元丧失及纹状体多巴胺含量显著减少,同时在神经元细胞质中产生泛素化蛋白沉

引用

页码：300 / 304

页数：5

共 9 条

[1]

Dopamine-modified[alpha]-synuclein blocks chaperone-mediated autophagy[J] . Martinez-Vicente, Marta,Talloczy, Zsolt,Kaushik, Susmita,Massey, Ashish C,Mazzulli, Joseph,Mosharov, Eugene V,Hodara, Roberto,Fredenburg, Ross,Wu, Du-Chu,Follenzi, Antonia,Dauer, William,Przedborski, Serge,Ischiropoulos, Harry,Lansbury, Peter T,Sulzer, David,Cuervo, Ana Maria.Journal of Clinical Investigation . 2008 (2)

[2] Silencing α-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells [J].

Liu, Dongmei ;

Jin, Ling ;

Wang, Hao ;

Zhao, Huanying ;

Zhao, Chunli ;

Duan, Chunli ;

Lu, Lingling ;

Wu, Bo ;

Yu, Shun ;

Chan, Piu ;

Li, Yaohua ;

Yang, Hui .

NEUROCHEMICAL RESEARCH, 2008, 33 (07) :1401-1409

[3] Heat shock proteins reduce α-synuclein aggregation induced by MPP+ in SK-N-SH cells [J].

Fan, Guo-Hua ;

Zhou, Hai-Yan ;

Yang, Hui ;

Chen, Sheng-Di .

FEBS LETTERS, 2006, 580 (13) :3091-3098

[4]

α-Synuclein facilitates the toxicity of oxidized catechol metabolites: Implications for selective neurodegeneration in Parkinson’s disease[J] . Takafumi Hasegawa,Michiko Matsuzaki-Kobayashi,Atsushi Takeda,Naoto Sugeno,Akio Kikuchi,Katsutoshi Furukawa,George Perry,Mark A. Smith,Yasuto Itoyama.FEBS Letters . 2006 (8)

[5]

α-Synuclein-positive structures induced in leupeptin-infused rats[J] . T. Nakajima,S. Takauchi,K. Ohara,M. Kokai,R. Nishii,S. Maeda,A. Takanaga,T. Tanaka,M. Takeda,M. Seki,Y. Morita.Brain Research . 2005 (1)

[6] Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease [J].

Shimoji, M ;

Zhang, L ;

Mandir, AS ;

Dawson, VL ;

Dawson, TM .

MOLECULAR BRAIN RESEARCH, 2005, 134 (01) :103-108

[7] Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation [J].

Parrini, C ;

Taddei, N ;

Ramazzotti, M ;

Degl'lnnocenti, D ;

Ramponi, G ;

Dobson, CM ;

Chiti, F .

STRUCTURE, 2005, 13 (08) :1143-1151

[8] α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication [J].

Miller, DW ;

Hague, SM ;

Clarimon, J ;

Baptista, M ;

Gwinn-Hardy, K ;

Cookson, MR ;

Singleton, AB .

NEUROLOGY, 2004, 62 (10) :1835-1838

[9]

Parkinson-like syndrome induced by continuous MPTP infusion:conver-gent roles of the ubiquitin-proteasome system and alpha-synuclein. Fornai F,Schluter OM,Lenzi Pet al. Proceedings of the National Academy of Sciences of the United States of America . 2005

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