培哚普利对充血性心力衰竭患者血浆细胞间粘附因子-1的影响

被引：7

作者：

王晓明

李源

李慧芳

龚卫琴

马峰

机构：

[1] 第四军医大学西京医院老年病科

[2] 第四军医大学西京医院心脏内科

来源：

临床心血管病杂志 | 2002年 / 02期

关键词：

心力衰竭,充血性; 培哚普利; 细胞间粘附因子-1;

D O I：

暂无

中图分类号：

R541.61 [];

学科分类号：

摘要：

目的 :探讨培哚普利对充血性心力衰竭 (CHF)患者血浆细胞间粘附因子 1(sICAM 1)水平的影响及心脏保护机制。方法 :用酶联免疫方法检测 42例服用培哚普利的CHF患者、42例常规治疗CHF患者治疗前后及 30例健康者血浆中sICAM 1水平。结果 :① 84例CHF患者血浆中sICAM 1为 ( 5 87.6± 15 2 .1) μg/L ,较健康者 ( 16 7.4± 34.6 ) μg/L显著增高 ( P<0 .0 0 1) ,且随着心功能损害程度加重而升高 ,各组间比较差异有显著性意义 (P <0 .0 5 )。②CHF培哚普利治疗组与常规治疗组治疗前后血浆中sICAM 1浓度〔分别为 ( 5 91.8± 15 5 .2 )、( 332 .1± 115 .8) μg/L ;( 5 80 .0± 134.4)、( 4 2 3.1± 118.1) μg/L〕水平差异有非常显著性意义 (P <0 .0 1) ,且培哚普利治疗组较常规治疗组治疗后血浆中sICAM 1降低更为明显 (P <0 .0 1)。结论 :培哚普利具有抑制CHF患者sICAM 1水平的作用 ,从而减缓心室重塑的进程 ,保护和改善心功能。

引用

页码：51 / 53

页数：3

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