肠道菌群与非酒精性脂肪肝相关性的研究进展

被引：32

作者：

陈默

孔银

王君

柳鹏程

王根年

魏丰贤

张岭漪

机构：

[1] 兰州大学第二临床医学院

来源：

中国微生态学杂志 | 2015年 / 27卷 / 08期

关键词：

肠道菌群; 非酒精性脂肪肝; 研究进展;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

非酒精性脂肪肝(NAFLD)是我国最常见的慢性肝病之一,为非酒精性因素所致的肝细胞脂肪变为特征的综合征,包括单纯性脂肪肝(SFL)、非酒精性脂肪性肝炎(NASH)及其相关肝硬化和肝细胞癌(HCC)。人体肠道中的各种菌群发挥着不同的病理生理作用,与许多疾病密切相关,肠道菌群可以通过"肠-肝轴"影响NAFLD的发生发展,"二次打击"学说很好地解释了NAFLD的发病机制及其与肠道菌群的关系。益生元、益生菌可以很好地调节肠道菌群,与抗生素和手术相比更加廉价、无害、安全,有望成为预防和治疗NAFLD的新方法。本研究对肠道菌群与NAFLD相关性的研究进展加以综述。

引用

页码：989 / 993

页数：5

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