microRNA调控自噬在心肌缺血再灌注中作用的研究进展

被引：2

作者：

胡丽华

王路乔

程晓曙

机构：

[1] 南昌大学第二附属医院心血管内科

来源：

生命的化学 | 2015年 / 35卷 / 02期

关键词：

microRNA; 自噬; 心肌缺血再灌注;

D O I：

10.13488/j.smhx.20150214

中图分类号：

R542.2 [心肌疾病];

学科分类号：

100201 [内科学];

摘要：

microRNA是一类转录后具有调节活性的内源性小分子RNA,通过与靶基因mRNA的3'UTR结合负性调控基因的表达从而参与多种心血管疾病的发生发展,其中对心肌缺血再灌注(I/R)的影响最为重要。microRNA通过调节自噬相关基因调控自噬。心肌细胞自噬对维持心功能具有重要作用,那么,在心肌I/R中,microRNA是否通过调节自噬来发挥作用呢?本文将对microRNA调控自噬在心肌缺血再灌注中作用机制进行综述。

引用

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页码：230 / 234

页数：5

相关论文

共 11 条

[1]

Effects of 3‐methyladenine on isolated left atria subjected to simulated ischaemia–reperfusion.[J].Romina Hermann;Débora Elisabet Vélez;Tatiana Mariel Rusiecki;María de las Mercedes Fernández Pazos;Victoria Evangelina Mestre Cordero;María Gabriela Marina Prendes;Juan Carlos Perazzo Rossini;Enrique Alberto Savino;Alicia Varela.Clin Exp Pharmacol Physiol.2015, 1

[2]

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9 [J].

Yang, Jurong ;

Chen, Dapeng ;

He, Yani ;

Melendez, Alicia ;

Feng, Zhe ;

Hong, Quan ;

Bai, Xueyuan ;

Li, Qinggang ;

Cai, Guangyan ;

Wang, Jianzhong ;

Chen, Xiangmei .

AGE, 2013, 35 (01) :11-22

[3]

The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease.[J].Thorp Edward B..Biochemistry Research International.2012,

[4]

Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation [J].

Zi-Long Zhang ;

Yan Fan ;

Mei-Lin Liu .

Molecular and Cellular Biochemistry, 2012, 365 :243-250

[5]

STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy [J].

McCormick, J. ;

Suleman, N. ;

Scarabelli, T. M. ;

Knight, R. A. ;

Latchman, D. S. ;

Stephanou, A. .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (02) :386-393

[6]

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice [J].

Patrick, David M. ;

Montgomery, Rusty L. ;

Qi, Xiaoxia ;

Obad, Susanna ;

Kauppinen, Sakari ;

Hill, Joseph A. ;

van Rooij, Eva ;

Olson, Eric N. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (11) :3912-3916

[7]

MicroRNAs Add a New Dimension to Cardiovascular Disease [J].

Small, Eric M. ;

Frost, Robert J. A. ;

Olson, Eric N. .

CIRCULATION, 2010, 121 (08) :1022-U66

[8]

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways [J].

Marcelo Fader, Claudio ;

German Sanchez, Diego ;

Belen Mestre, Maria ;

Colombo, Maria Isabel .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2009, 1793 (12) :1901-1916

[9]

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy.[J]..Hypertension.2009, 6

[10]

Autophagy in Ischemic Heart Disease [J].

Gustafsson, Asa B. ;

Gottlieb, Roberta A. .

CIRCULATION RESEARCH, 2009, 104 (02) :150-158