β-胡萝卜素的抗肿瘤作用及其分子机制研究进展

被引：19

作者：

王景川

庞广昌

机构：

[1] 天津市食品生物技术重点实验室,天津商业大学生物技术与食品科学学院

来源：

食品科学 | 2008年 / 10期

关键词：

β-胡萝卜素; 肿瘤; 细胞凋亡; 分子机制;

D O I：

暂无

中图分类号：

R151 [营养学];

学科分类号：

100403 ;

摘要：

β-胡萝卜素可以抑制乳腺癌、结肠癌、白血病、黑色素瘤以及前列腺癌等多种肿瘤细胞的增殖,并能通过激活caspase-2和caspase-8、降低线粒体膜电位(Δψm)、增加细胞色素C的释放、调节核因子-κB(NF-κB)途径、抑制激活蛋白-1(AP-1)、下调抗凋亡蛋白Bcl-2、Bcl-XL和c-myc的表达、上调过氧化酶体增殖因子受体-γ(PPAR-γ)以及热休克蛋白70(Hsp70)和Hsp90的水平等机制促进肿瘤细胞凋亡。β-胡萝卜素的抗肿瘤作用与其对细胞内氧化还原状态的调节作用有关。而且,β-胡萝卜素促细胞凋亡的各种机制具有多效性,这些机制很可能是协同作用的,可见弄清楚其分子机制也为早日将β-胡萝卜素开发为功能性食品,应用于癌症的辅助治疗奠定理论基础。

引用

页码：665 / 669

页数：5

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