氨磺必利治疗精神分裂症40例临床疗效初探

被引:51
作者
邝云航 [1 ]
李小芳 [2 ]
钟潇琦 [2 ]
李侠才 [1 ]
机构
[1] 广东省梅州市第三人民医院
[2] 广州市精神病医院
关键词
氨磺必利; 精神分裂症;
D O I
暂无
中图分类号
R749.3 [精神分裂症];
学科分类号
摘要
目的探讨氨磺必利治疗精神分裂症患者的临床疗效。方法选择符合条件的精神分裂症患者40例,阳性亚型组以≥400mg/d为起始剂量,阴性亚型组以100~300mg/d为起始剂量的氨磺必利治疗10周,疗效评定采用阳性与阴性量表(PANSS)。结果治疗结束时,痊愈5.1%,显效69.2%,有效25.6%,PANSS量表总分及分量表分与治疗前比较均有显著性差异。结论氨磺必利对精神分裂症的阳性及阴性症状均有疗效,且以较低剂量即能明显改善阴性症状为突出特点。
引用
收藏
页码:180 / 181
页数:2
相关论文
共 9 条
  • [1] I mprovement of acute exacerbations of schizophrenia with amisulpride:a compari-son with haloperidol.PROD-ASLP Study Group. Mller HJ,Boyer P,Fleurot O,et al. Psychopharmacology . 1997
  • [2] Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology-a double-blind controlled study comparing a selective D2 -like antagonist to a mixed D1 - D2 -like antagonist. Wetzel H,Grunder G,Hillert A,et al. Psychopharmacology . 1998
  • [3] From pharmacological profiles to clinical out-comes. Kerwin R. International Clinical Psychopharmacology . 2000
  • [4] Amisulpride vs. risperidone in the treatment of acute exacerbations of schizophrenia. Peuskens,J,Bech,P,M?ller,HJ,Bale,R,Fleurot,O,Rein,W. Psychiatry Research . 1999
  • [5] Psychopharmacological profile of amisulpride.An antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. Perrault G H,Depoortere D,Morel E,et al. Journal of Pharmacology and Experimental Therapeutics . 1997
  • [6] Neurochemical characteristics of Amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. Schoemaker H,Claustre Y,Fage D,et al. Journal of Pharmacology and Experimental Therapeutics . 1997
  • [7] Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology – a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist[J] . H. Wetzel,G. Gründer,A. Hillert,M. Philipp,W. F. Gattaz,H. Sauer,G. Adler,J. Schr?der,W. Rein,O. Benkert. &nbspPsychopharmacology . 1998 (3)
  • [8] Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol[J] . H. J. M?ller,P. Boyer,O. Fleurot,W. Rein. &nbspPsychopharmacology . 1997 (4)
  • [9] Amisulpride:from ani mal pharmacology to therapeutic action. Scatton B,Claustre Y,Cudennec A,et al. Int Clin Psy-chopharmacol . 1997