莽草酸对大鼠大脑中动脉血栓所致局部脑缺血性损伤的拮抗作用<英文>

被引：10

作者：

马怡

徐秋萍

孙建宁

白丽敏

郭亚健

牛建昭

机构：

[1] 北京中医药大学药理教研室

[2] 北京中医药大学药理教研室北京中国 Now in Depcutment of Pharmacology

[3] Capital University of Medical Science

[4] Beijing China

[5] 北京中国

来源：

ActaPharmacologicaSinica | 1999年 / 08期

关键词：

莽草酸; 脑动脉; 血栓形成; 脑缺血; 脑梗死; 脑水肿; 川芎嗪;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的:研究莽草酸（SA）对大脑中动脉血栓所致局部脑缺血的影响。方法:用三氯化铁局部涂抹损伤血管形成的大鼠大脑中动脉血栓模型（MCAT）观察SA对行为障碍程度、脑梗塞范围、脑水肿和缺血区脑血流的影响。结果:SA 25、50mg·kg-1 ip于MCAT前连续给药3d可分别减小脑梗塞范围51％、42％,使脑含水量由80.7％降致79.8％、79.9％,并可改善行为障碍程度和缺血区脑血流量的降低,病理检查显示,SA 25mg·kg-1组动物MCA内血栓形成极少,脑组织缺血病变较轻。结论:SA可减轻大脑中动脉血栓所致局部脑缺血性损伤。

引用

页码：3 / 5

页数：4

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