氧化应激与糖尿病周围神经病变的研究进展

被引：58

作者：

张倩

梁晓春

机构：

[1] 中国医学科学院北京协和医学院,北京协和医院中医科

来源：

中华内分泌代谢杂志 | 2015年 / 31卷 / 11期

关键词：

糖尿病周围神经病变; 氧化应激; 活性氧簇;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

氧化应激在糖尿病周围神经病变的发病机制中起到了关键作用。高血糖可引起线粒体电子传递链异常、NADPH氧化酶激活等生成活性氧簇, 氧化损伤脂质、DNA、蛋白质, 促进多个糖尿病周围神经病变的经典病理途径, 诱导神经元和雪旺细胞凋亡, 神经组织炎症, 导致神经损伤。本文就氧化应激与糖尿病周围神经病变发病机制进行综述, 为进一步探讨治疗策略提供线索。

引用

共 36 条

[1]

Oxidative, Metabolic, and Apoptotic Responses of Schwann Cells to High Glucose Levels [J].

Cinci, Lorenzo ;

Corti, Francesca ;

Mannelli, Lorenzo Di Cesare ;

Micheli, Laura ;

Zanardelli, Matteo ;

Ghelardini, Carla .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2015, 29 (06) :274-279

[2]

Oxidative stress predicts progression of peripheral and cardiac autonomic nerve dysfunction over 6 years in diabetic patients [J].

Ziegler, Dan ;

Buchholz, Stefanie ;

Sohr, Christoph ;

Nourooz-Zadeh, Jaffar ;

Roden, Michael .

ACTA DIABETOLOGICA, 2015, 52 (01) :65-72

[3]

Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats [J].

Yu, Ting ;

Li, Lei ;

Bi, Yanwen ;

Liu, Zhen ;

Liu, Huaxiang ;

Li, Zhenzhong .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2014, 66 (08) :1150-1160

[4]

Recent advances in understanding the role of oxidative stress in diabetic neuropathy [J].

Shakeel, Manal .

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2015, 9 (04) :373-378

[5]

Zinc Supplementation Alleviates Diabetic Peripheral Neuropathy by Inhibiting Oxidative Stress and Upregulating Metallothionein in Peripheral Nerves of Diabetic Rats [J].

Liu, Fangyao ;

Ma, Feiyu ;

Kong, Gengbin ;

Wu, Kezhou ;

Deng, Zhihua ;

Wang, Hu .

BIOLOGICAL TRACE ELEMENT RESEARCH, 2014, 158 (02) :211-218

[6]

Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on These Targets.[J].Reddemma Sandireddy;Veera Ganesh Yerra;Aparna Areti;Prashanth Komirishetty;Ashutosh Kumar;Durga N. Tripathi.International Journal of Endocrinology.2014,

[7]

Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord.[J].Wei-Cheng Zhao;Bin Zhang;Mei-Juan Liao;Wen-Xuan Zhang;Wan-You He;Han-Bing Wang;Cheng-Xiang Yang.Neuroscience Letters.2014,

[8]

Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy.[J].Ghulam Mohammad;Mohammad Mairaj Siddiquei;Ahmed M. Abu El-Asrar;Dorota Raczynska.Mediators of Inflammation.2013,

[9]

Bradykinin B 1 antagonism inhibits oxidative stress and restores Na+K+ ATPase activity in diabetic rat peripheral nervous system.[J].Orlando Catanzaro;Jorgelina Aria Capponi;Jose Michieli;Emilio Labal;Irene Di Martino;Pierre Sirois.Peptides.2013,

[10]

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy [J].

Yerra, Veera Ganesh ;

Negi, Geeta ;

Sharma, Shyam S. ;

Kumar, Ashutosh .

REDOX BIOLOGY, 2013, 1 (01) :394-397

← 1 2 3 4 →