他汀类药物对缺血性脑卒中相关性肺炎的预防作用

被引：4

作者：

张素花

赵红东

李秀华

机构：

[1] 南京医科大学附属南京医院

来源：

内科急危重症杂志 | 2018年 / 24卷 / 04期

关键词：

急性缺血性脑卒中; 卒中相关性肺炎; 他汀类药物; 吞咽困难; 危险因素;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

目的:调查他汀类药物对急性缺血性脑卒中患者并发卒中相关性肺炎(SAP)的预防作用。方法:回顾性分析3492例急性缺血性脑卒中患者的临床资料,并采用logistic回归分析预测发生SAP的危险因素。结果:97例患者死亡,489例患者发生SAP,使用他汀类药物的患者SAP发生率显著低于未使用该药物的患者(12. 0%vs 17. 2%,P <0. 01),多因素分析显示,年龄、改良Rankin量表(mRS)评分、国立卫生研究院卒中量表(NIHSS)评分、吞咽困难、合并心源性栓塞和未采用他汀类药物治疗是SAP发生的危险因素;在调整其他危险因素后,吞咽困难OR值最高(OR=3. 71,95%CI:2. 7～5. 1)。多因素logistic回归分析显示未接受他汀类药物治疗、mRS评分和不明原因的诊断会影响病死率,发生SAP的OR值最高(OR:5. 62,95%CI:3. 40～9. 29)。结论:SAP是患者死亡的主要危险因素,他汀类药物能预防急性缺血性脑卒中患者SAP的发生,并可改善患者的预后。

引用

页码：281 / 284+288 +288

页数：5

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