神经肽的免疫调节作用

被引：6

作者：

王霞

周江睿

蒋春雷

机构：

[1] 第二军医大学军事航海医学教研室

来源：

现代生物医学进展 | 2012年 / 12卷 / 26期

关键词：

神经肽Y; 炎症; 免疫; cAMP-PKA;

D O I：

10.13241/j.cnki.pmb.2012.26.055

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

机体自我免疫耐受的降低或者破坏会导致免疫系统的失衡,并加重炎症反应过程,从而引发多种自身免疫性疾病。所以诱导免疫耐受并终止炎症反应对恢复机体健康具有十分重要的意义。最近研究发现机体在炎症反应过程中会释放一类神经肽,如VIP,urocortin,ghrelin等。这些神经肽可下调固有免疫应答,抑制抗原特异性Th 1细胞分化,诱导调节性T细胞的产生,维持免疫耐受,并终止炎症反应。神经肽的这种抑炎作用主要是通过激活cAMP-PKA通路以及调节与免疫炎症因子表达相关的信号通路来实现的。神经肽有可能成为治疗炎症性疾病的一类新药物。

引用

收藏

页码：5189 / 5191

页数：3

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