肾素-血管紧张素-醛固酮系统基因与高血压患者发生心血管事件相关性研究进展

被引：17

作者：

朱玮玮

华琦

机构：

[1] 首都医科大学宣武医院心脏科

来源：

心血管病学进展 | 2015年 / 36卷 / 04期

关键词：

肾素-血管紧张素-醛固酮系统; 基因; 高血压; 心血管事件;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

100201 [内科学];

摘要：

心血管疾病是目前很多国家的主要死亡原因之一。另外高血压病是中国心血管疾病中发病率最高的疾病,血压的持续升高在心脑血管疾病的发生发展过程中起着重要作用。肾素-血管紧张素-醛固酮系统的过度激活是高血压机制之一。研究表明肾素-血管紧张素-醛固酮系统基因与心血管疾病、高血压、左室肥厚和心肌梗死有关。这些基因变异可能在整个生命活动中起作用,从而可能增加心脑血管疾病风险。但目前少见上述基因预测高血压患者发生心血管事件的研究,现就此问题进行综述。

引用

页码：394 / 397

页数：4

共 14 条

[1]

Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension..Farrag Wael;Eid Manal;El-Shazly Sherien;Abdallah Manal;.Molecular and cellular biochemistry.2011,

[2]

Hypertension and depressed symptomatology: A cluster related to the activation of the renin–angiotensin–aldosterone system (RAAS). Findings from population based KORA F4 study.[J].S. Häfner;J. Baumert;R.T. Emeny;M.E. Lacruz;M. Bidlingmaier;M. Reincke;K.H. Ladwig.Psychoneuroendocrinology.2013, 10

[3]

Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in Calabar and Uyo cities; Nigeria.[J].Kooffreh; Mary;Anumudu; Chiaka;Duke; Roseline;Okpako; Elza;Kumar; P.Indian Journal of Human Genetics.2013, 2

[4]

Measuring and targeting aldosterone and renin in atherosclerosis-A review of clinical data [J].

Hillaert, Marieke A. ;

Lentjes, Eef G. ;

Beygui, Farzin ;

Kemperman, Hans ;

Asselbergs, Folkert W. ;

Nathoe, Hendrik M. ;

Agostoni, Pierfrancesco ;

Voskuil, Michiel ;

Ivanes, Fabrice ;

Jude, Brigitte ;

Bertrand, Michel E. ;

Pasterkamp, Gerard ;

van der Graaf, Yolanda ;

Doevendans, Pieter A. ;

Montalescot, Gilles ;

Van Belle, Eric .

AMERICAN HEART JOURNAL, 2011, 162 (04) :585-596

[5]

Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals [J].

Johnson, Andrew D. ;

Newton-Cheh, Christopher ;

Chasman, Daniel I. ;

Ehret, Georg B. ;

Johnson, Toby ;

Rose, Lynda ;

Rice, Kenneth ;

Verwoert, Germaine C. ;

Launer, Lenore J. ;

Gudnason, Vilmundur ;

Larson, Martin G. ;

Chakravarti, Aravinda ;

Psaty, Bruce M. ;

Caulfield, Mark ;

van Duijn, Cornelia M. ;

Ridker, Paul M. ;

Munroe, Patricia B. ;

Levy, Daniel .

HYPERTENSION, 2011, 57 (05) :903-U99

[6]

Candidate Gene Polymorphisms of Renin Angiotensin System and Essential Hypertension in a South Indian Tamilian Population [J].

Ramu, P. ;

Umamaheswaran, G. ;

Shewade, D. G. ;

Swaminathan, R. P. ;

Dutta, T. K. ;

Balachander, J. ;

Adithan, C. .

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2011, 11 (01) :31-40

[7]

The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease [J].

Vaisi-Raygani, Asad ;

Ghaneialvar, Hori ;

Rahimi, Zohreh ;

Nomani, Hamid ;

Saidi, Mohmadreza ;

Bahrehmand, Fariborz ;

Vaisi-Raygani, Aliakbar ;

Tavilani, Haidar ;

Pourmotabbed, Tayebeh .

CLINICAL BIOCHEMISTRY, 2010, 43 (15) :1189-1194

[8]

The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis [J].

Niemiec, Pawell ;

Zak, Iwona ;

Wita, Krystian .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2008, 46 (04) :446-452

[9]

UPREGULATION OF ANGIOTENSIN AT<sub>1</sub> RECEPTOR AND INTRACELLULAR KINASE GENE EXPRESSION IN HYPERTENSIVE RATS.[J].Valin Reja;Ann K Goodchild;Jacqueline K Phillips;Paul M Pilowsky.Clinical and Experimental Pharmacology and Physiology.2006, 8

[10]

Angiotensin II Sensitivity Is Associated With the Angiotensin II Type 1 Receptor A1166C Polymorphism in Essential Hypertensives on a High Sodium Diet.[J].Wilko Spiering;Abraham A. Kroon;Monique M. J. J. Fuss-Lejeune;Mat J. A. P. Daemen;Peter W. de Leeuw.Hypertension: Journal of the American Heart Association.2000, 3

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