中草药对PXR的调节作用

被引：3

作者：

胡东莉

刘丽娟

王果

周宏灏

机构：

[1] 中南大学临床药理研究所

来源：

现代生物医学进展 | 2010年 / 10卷 / 20期

关键词：

孕烷X受体; 中草药; 调节;

D O I：

10.13241/j.cnki.pmb.2010.20.015

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

孕烷X受体(Pregnane X Receptor,PXR)是转录调控因子,参与大量的外源性和内源性化学物质的生物转化,这些物质都能激活PXR如胆汁酸、胆红素、某些维生素等。PXR还参与各种生理/病理过程,如脂代谢、糖代谢和炎症。PXR的配体结构多种多样,越来越多的患者在接受西药治疗的同时服用中药作为替代补充治疗的手段。中药的合用增加了临床上中西药发生相互作用和不良反应的风险,导致病患对化疗药物疗效不佳或产生毒性反应。本文主要关注中药对PXR的调节作用。

引用

页码：3980 / 3983

页数：4

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