线粒体功能障碍与心肌缺血再灌注损伤

被引：18

作者：

李冬 ^{[1
]}

史大卓 ^{[2
]}

刘秀华 ^{[3
]}

机构：

[1] 北京中医药大学

[2] 中国中医科学院西苑医院

[3] 解放军总医院病理生理学研究室

来源：

中华老年心脑血管病杂志 | 2014年 / 16卷 / 03期

关键词：

线粒体; 心肌再灌注损伤; 心肌梗死; 肌细胞,心脏;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

<正>近年来,随着溶栓治疗、冠状动脉旁路移植术、PCI等在临床的广泛应用,再灌注损伤越来越受到广泛的关注。心肌缺血再灌注损伤是指经历一定时间缺血的心肌组织在恢复血流灌注后损伤加重的现象,包括心律失常、心肌收缩功能下降和再灌注心肌不可逆损伤等。在再灌注损伤过程中,线粒体(mitochondria)功能障碍是一个非常重要的病理机制,包括线粒体ATP生成减少、Ca2+过荷、活性氧大量产生

引用

页码：318 / 321

页数：4

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