银屑病患者外周血Th1细胞分化偏态性分析

被引:12
作者
何玉清
张锡宝
费实
刘玉梅
吴志华
机构
[1] 广州市皮肤病防治所
[2] 广东医学院附属医院皮肤科
[3] 广东省湛江市霞山区
关键词
银屑病; Th1分化偏态性; 细胞因子; 流式细胞术;
D O I
暂无
中图分类号
R758.63 [牛皮癣(银屑病)];
学科分类号
100206 ;
摘要
目的:探讨银屑病患者外周血辅助性T(Th)细胞亚群的分化取向及其在银屑病发病机制中的作用。方法:采用流式细胞术检测经三色荧光抗体染色的银屑病患者外周血CD8-/IFN-γ+(Th1)和CD8-/IL-4+(Tha)细胞含量。结果:银屑病组Tg1细胞含量明显高于正常对照组(P<0.01);银屑病组存在Th1细胞分化偏态性。结论:银屑病患者外周血T细胞亚群分化失衡及Th1细胞分泌的细胞因子是银屑病发生发展的相关因素。
引用
收藏
页码:1 / 4
页数:4
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