成骨细胞调节破骨细胞功能的机制及途径研究进展

被引:8
作者
王瑞 [1 ,2 ,3 ]
杨谛 [1 ,2 ,3 ]
机构
[1] 中国医科大学口腔医学院附属口腔医院
[2] 辽宁省口腔疾病重点实验室
[3] 中国医科大学口腔医学院中心实验室
关键词
成骨细胞; 破骨细胞; 旁分泌途径; 近分泌途径; 成骨细胞调节破骨细胞; 细胞凋亡;
D O I
暂无
中图分类号
R329.2 [人体细胞学];
学科分类号
100107 [人体解剖与组织胚胎学(人体解剖学、组织与胚胎学)];
摘要
成骨细胞与破骨细胞是骨重塑、修复过程中重要的细胞,成骨细胞主要起骨形成作用,破骨细胞主要介导骨吸收,两者关系十分密切。成骨细胞参与破骨细胞骨吸收功能调节,可以调节破骨细胞在骨表面附着、分化,诱导破骨细胞凋亡,抑制破骨细胞骨吸收。成骨细胞通过三种方式调节破骨细胞,包括旁分泌、近分泌及旁分泌、近分泌协同。旁分泌包括成骨细胞产生细胞因子作用于破骨细胞,以及破骨细胞吸收骨基质释放基质中的成骨细胞合成的细胞因子,近分泌包括直接接触及缝隙连接,旁分泌、近分泌两者协同发挥作用。
引用
收藏
页码:112 / 115
页数:4
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