2型糖尿病患者的认知功能与血浆BDNF水平

被引：15

作者：

周红 ^{[1
,2
]}

常京豪 ^{[1
,3
,4
]}

张志珺 ^{[1
,2
]}

滕皋军 ^{[4
]}

机构：

[1] 东南大学附属中大医院神经内科

[2] 东南大学脑血管病研究所

[3] 苏州市立医院老年科

[4] 东南大学分子影像研究中心

来源：

中国神经精神疾病杂志 | 2010年 / 36卷 / 05期

关键词：

2型糖尿病; 认知功能; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R749.24 [];

学科分类号：

100205 ;

摘要：

目的探讨2型糖尿病(diabetes mellitus,DM)患者认知功能特征及其与血浆脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平的关系。方法应用多维度神经心理学量表评估年龄及教育程度相匹配的89例2型DM患者及40例对照者的神经认知功能,并结合Peterson的遗忘型轻度认知功能障碍(amnesic mildcognitive impairment,aMCI)标准判定两组中的aMCI患者;采用酶联免疫吸附试验检测血浆BDNF水平。结果 2型DM组连线测试B(trial marking test B,TMTB)、听觉词语记忆测试-延迟回忆和再认(delayed recall and recogni-tion of auditory verbal learning test,AVLT-DR&RC)、符号数字转换测试(symbol digit modulation test,SDMT),词语流畅性测试(verbal fluency test,VFT)及画钟测试(clock drawing test,CDT)成绩均明显差于对照组(均P<0.01);2型DM与aMCI有较强的关联性[OR=4.032(1.536～10.582)],2型DM中aMCI者AVLT-DR&RC、VFT、TMTB、CDT、连线测试A(trial marking test A,TMTA)、复杂图形测试-延迟回忆(delayed recall of Rey-Osterrich complex figure test,CFT-DR)成绩均明显差于2型DM非aMCI组(P<0.05);2型DM组血浆BDNF水平明显低于对照组(P<0.01),但与各项认知评估成绩无相关性(P>0.05),仅2型DM组aMCI者血浆BDNF水平与SDMT及CFT-DR测试成绩呈正相关(分别为r=0.522,P<0.01;r=0.346,P<0.05)。结论 2型DM患者可出现认知功能损伤,并伴血浆BDNF水平降低;但2型DM的认知功能改变与BDNF水平之间的关系有待进一步研究证实。

引用

页码：286 / 291

页数：6

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