巨噬细胞与动脉粥样硬化及中医药干预作用研究进展

被引：27

作者：

王俊岩

郑思成

王丹

张林

杨关林

陈文娜

贾连群

机构：

[1] 辽宁中医药大学中医脏象理论及应用教育部重点实验室

来源：

辽宁中医杂志 | 2017年 / 44卷 / 01期

关键词：

动脉粥样硬化; 巨噬细胞; 凋亡; 自噬; 极化;

D O I：

10.13192/j.issn.1000-1719.2017.01.072

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

动脉粥样硬化是全球的常见病、多发病,同时是导致心脑血管疾病的主要的病理基础,严重影响到人类生命健康。AS一个慢性炎性反应的过程,高脂血症、高血压、高血糖、高尿酸、肥胖等多种因素导致血管内皮损伤,血管壁增厚,弹性改变等一系列变化。在AS发生的不同阶段,巨噬细胞凋亡、自噬分别发挥着不同的作用,以及不同表型的巨噬细胞在AS的进程中也发挥着不同作用,适度的凋亡和自噬会降低炎症反应发生,保证AS斑块的稳定性,将M1型巨噬细胞向M2型巨噬细胞极化亦会增强AS斑块的稳定性,减少临床不良事件的发生。文章就巨噬细胞凋亡、自噬和极化等与AS发生发展的关系以及中医药干预作用研究进展作一综述,为临床防治AS以及新药研发提供新的理论依据。

引用

收藏

页码：214 / 217

页数：4

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