脑源性神经营养因子在抑郁症发作病理机制中的作用

被引：19

作者：

李则挚

洪武

方贻儒

机构：

[1] 上海交通大学医学院附属精神卫生中心心境障碍科

来源：

上海交通大学学报(医学版) | 2010年 / 30卷 / 06期

基金：

国家科技攻关计划;

关键词：

脑源性神经营养因子; 抑郁症; 病理机制;

D O I：

暂无

中图分类号：

R749.41 [];

学科分类号：

摘要：

抑郁症的脑源性神经营养因子(BDNF)假说认为,BDNF减少在抑郁症的病理生理机制中起着重要的作用,而且其恢复可能与抗抑郁治疗有关。该理论已经得到了越来越多的新证据证明。BDNF能通过多种途径调控神经细胞的发生、生存、生长、分化和凋亡,并直接参与了神经突触的可塑性和重构,这可能是BDNF参与抑郁症发病和治疗的重要机制。该文就近来的BDNF与抑郁症的相关研究进行综述。

引用

页码：651 / 655

页数：5

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