人食管癌相关核基质蛋白的初步研究

被引:5
作者
李冠武
温博贵
陈爱云
机构
[1] 汕头大学医学院病理系生物化学与分子生物学研究室!广东汕头
[2] 中国科技大学生命科学学院分子细胞生物学系
[3] 安徽合肥
关键词
食管肿瘤; 核基质; 肿瘤标志物;
D O I
10.13431/j.cnki.immunol.j.20010038
中图分类号
R735.1 [食管肿瘤];
学科分类号
摘要
目的从核基质蛋白中探寻人食管癌肿瘤标志物。方法用高盐抽提法制备核基质 ,免疫动物获取抗血清 ,Western Blot检测特异性。结果食管癌细胞中出现一条阳性条带 ,其代表的蛋白约为 12 6 0 0 0 u,除食管癌原发的贲门癌外 ,这一阳性条带均未在正常食管和所检测的其它几种肿瘤细胞中出现。结论食管癌细胞核基质中存在 1个或 1组表观分子量为12 6 0 0 0 u的相关多肽 ,可能与食管癌的发生发展有关 ,并且有一定的诊断价值
引用
收藏
页码:113 / 115+122 +122
页数:4
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