mTOR通路在肿瘤骨转移中的作用

被引：4

作者：

朱志伦 ^{[1
]}

刘子博 ^{[1
]}

孙伟伟 ^{[1
,2
]}

机构：

[1] 南京医科大学基础医学院

[2] 南京医科大学人体解剖学系

来源：

中国肿瘤生物治疗杂志 | 2018年 / 25卷 / 08期

关键词：

肿瘤; 骨转移; mTOR通路; 骨代谢;

D O I：

暂无

中图分类号：

R73-37 [肿瘤的转移与扩散];

学科分类号：

100214 [肿瘤学];

摘要：

超过25%的实体瘤患者在晚期都会出现不同程度的骨转移。发生骨转移的肿瘤细胞与骨微环境内细胞相互作用,骨稳态被打破,建立起促进肿瘤生长、加速骨质破坏的恶性循环,进一步促进肿瘤细胞在骨髓腔中浸润,导致转移的级联反应。肿瘤骨转移是一个复杂的过程,大量分子和信号通路参与其中。研究证实,哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路活性的改变与肿瘤细胞的骨转移以及转移后骨质破坏密切相关。本文从肿瘤细胞的脱落、迁移、黏附和侵入等转移步骤以及骨代谢变化两方面对mTOR信号通路在肿瘤骨转移过程中的作用进行阐述,为肿瘤骨转移的预防和治疗提供新的方向。

引用

页码：830 / 833

页数：4

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