冠状动脉旁脂肪促进冠状动脉粥样硬化的研究进展

被引：3

作者：

岳丽军

徐天舒

机构：

[1] 南京大学医学院附属鼓楼医院中医科

来源：

中华临床医师杂志(电子版) | 2014年 / 8卷 / 24期

关键词：

动脉粥样硬化; 血管滋养管; 巨噬细胞; 冠状动脉心包脂肪组织; 易损斑块;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

近年来随着对全身脂肪、循环脂质水平升高与冠心病发病关系的临床证据和基础研究的深入,越来越充分的证据表明脂肪组织通过旁分泌、自分泌炎症因子加重全身血管炎症状态、介导胰岛素抵抗、促进血液高凝等途径直接导致冠心病等血管性疾病的发病率大幅增加。传统的冠状动脉粥样硬化理论认为冠状动脉粥样硬化起始于高血压、高血脂、高血糖和其他血管内危险因素导致的血管内皮损伤,继而引起内皮功能紊乱、内膜增生、炎症细胞趋化、脂质累积,最终这些"由内而外"的因素导致动脉粥样硬化斑块的形成,新近的研究渐渐把这种"由外而内"的发病机制和传统的由血管内因素(血浆脂质)异常到内皮功能损害、内膜增殖、脂质斑块形成联系起来,最近的证据表明新生滋养血管与血管壁重构是冠状动脉旁脂肪促进动脉粥样硬化斑块易损的两个重要机制。本文基于现有临床和实验方面的最新证据,阐明冠状动脉旁脂肪组织参与整个动脉粥样硬化的时间和空间过程。

引用

页码：4475 / 4479

页数：5

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