新型糖皮质激素在炎症性肠病治疗中有效性和安全性的研究现状(英文)

被引：18

作者：

艾佳

黄奇

缪应雷

机构：

[1] 昆明医科大学第一附属医院消化内科

来源：

昆明医科大学学报 | 2014年 / 35卷 / 06期

关键词：

炎症性肠病; 溃疡性结肠炎; 克罗恩病; 系统激素; 糖皮质激素; 布地奈德; 倍氯米松;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

炎症性肠病包括溃疡性结肠炎和克罗恩病,全世界约有2 500 000人患有此病.其病因可能是基因易感人群对肠道菌群的免疫应答失调.传统糖皮质激素能有效诱导活动期疾病缓解,但同时伴有诸多全身副作用.新型糖皮质激素如布地奈德和倍氯米松,粘膜吸收、灭活迅速,起效快,抗炎作用强且全身副作用少.这些新型制剂口服后被小肠的吸收,特异地释放于肠道粘膜,发挥其强大的抗炎作用.就新型糖皮质激素在炎症性肠病治疗中的有效性和安全性做简要评估和总结.

引用

页码：167 / 173+180 +180

页数：8

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