髓源抑制细胞在肿瘤微环境中的研究进展

被引：21

作者：

郝文斌

相芬芬

刘巧丽

乐红红

康向东

机构：

[1] 上海中医药大学附属普陀医院检验科

来源：

免疫学杂志 | 2017年 / 08期

关键词：

髓源抑制细胞; 免疫逃逸; 级联效应;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

髓源抑制细胞(myeloid-derived suppressor cells,MDSCs)是肿瘤微环境的主要成分之一。这些细胞的主要特征是具有强效的免疫抑制活性。MDSCs与肿瘤细胞之间通过高度的级联效应相互作用,从而导致肿瘤细胞逃避免疫系统的监视而进一步发展。癌症免疫治疗的精髓是促进机体免疫系统攻击肿瘤细胞,本文就近几年来关于MDSCs协助肿瘤免疫逃逸,肿瘤对MDSCs募集的机制以及中医药对MDSCs调控中的作用做一综述。

引用

页码：729 / 732

页数：4

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