多巴胺与免疫反应调节的研究进展

被引：11

作者：

黄洁 ^{[1
,2
]}

徐格致 ^{[1
]}

机构：

[1] 复旦大学附属眼耳鼻喉科医院眼科

[2] 复旦大学上海医学院

来源：

复旦学报(医学版) | 2018年 / 45卷 / 05期

关键词：

多巴胺; 多巴胺受体; 免疫; 白细胞; 炎症;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

神经递质多巴胺(dopamine,DA)是联接神经和免疫的重要分子。白细胞能合成和转运DA,几乎所有的免疫细胞亚群都表达DA受体,DA与其受体结合,通过自分泌/旁分泌方式调节免疫细胞的活化、增殖和细胞因子分泌。在中枢神经系统和外周组织,DA主要通过D1和D2受体抑制或加强免疫效应细胞的功能。中枢神经系统退行性疾病表现出免疫功能失调,可能与免疫细胞上DA受体表达水平以及信号传导通路的变化相关。因此,选择性针对免疫细胞的DA受体激动剂或拮抗剂在治疗DA介导的免疫失调性疾病中可能发挥重要作用。本文就DA受体在免疫细胞上的表达、DA作为免疫调节分子的作用以及在免疫功能障碍相关疾病中的研究进展作一综述。

引用

页码：722 / 726+734 +734

页数：6

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