脑星形细胞瘤PCNA表达的免疫组化研究

被引:11
作者
张建国
李龄
刘绍春
赵时宇
机构
[1] 北京市神经外科研究所
[2] 同济医科大学附属同济医院神经外科
[3] 同济医科大学病理教研室
关键词
增殖细胞核抗原; 星形细胞瘤; 复发; 免疫组织化学;
D O I
暂无
中图分类号
R739.4 [神经系肿瘤];
学科分类号
摘要
采用抗PCNA单克隆抗体PC10对54例星形细胞瘤进行免疫组化研究,结果显示,PCNA阳性表达主要定位于胞核,少数亦有胞浆表达,并与细胞周期中的S期密切相关,PCNA平均指数在星形细胞瘤Ⅰ、Ⅱ、Ⅲ—Ⅳ级间存在显著差异(P<0.01),复发组亦高于原发组(P<0.05),随着肿瘤恶性度增高,PCNA反应强度也增强,病人预后越差,表明PCNA平均指数可作为星形细胞瘤组织学分级和预后判断的可靠指标。
引用
收藏
页码:161 / 163
页数:3
相关论文
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