阿托伐他汀对大鼠心肌梗死后心室重塑和心功能的影响

被引：1

作者：

施冰 ^{[1
]}

冬兰 ^{[1
]}

崔新娟 ^{[2
]}

赵倩 ^{[1
]}

王珺 ^{[1
]}

机构：

[1] 北京军区总医院干部病房一科

[2] 北京军区总医院保健科

来源：

中国临床保健杂志 | 2012年 / 15卷 / 02期

关键词：

心肌梗死; 心室重构; 心血管生理过程; 降血脂药; 大鼠,Sprague-Dawley;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的观察阿托伐他汀对大鼠急性心肌梗死后心室重塑和心功能的影响。方法 20只雄性SD大鼠通过前降支动脉结扎法建立大鼠急性心肌梗死模型后随机分为心肌梗死组(AMI),阿托伐他汀组(ATV),另设假手术组,每组n=10。阿托伐他汀组每天给予阿托伐他汀钙片(10 mg.kg-1.d-1)灌胃,持续4周。假手术组和心肌梗死组每天给予同等量的0.9%氯化钠注射溶液灌胃。治疗前后分别测量3组大鼠的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)和短轴缩短率(LVFS)。大鼠处死后,测量左心室重量及左心重量指数。采用羟胺氧化法测定大鼠血清超氧化物歧化酶活力(SOD)。采用TBA法测定血清丙二醛(MDA)水平。结果治疗4周后,与正常组比较,心肌梗死组和阿托伐他汀组的左心室重量及左心室重量指数均显著增加。与心肌梗死组比较,阿托伐他汀组的左心室重量及左心室重量指数均显著降低,LVEDD、LVESD明显降低,LVEF显著升高。血清超氧化物歧化酶活力显著增强,血清丙二醛水平下降。结论阿托伐他汀可能通过抗氧化作用,改善心肌梗死后大鼠心室重构和左心室功能,防治心室重塑。

引用

页码：164 / 166

页数：3

共 6 条

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