IgE介导的食物过敏诊断程序及临床评价

被引:27
作者
邵洁
夏振炜
李云珠
俞善昌
机构
[1] 上海交通大学医学院附属瑞金医院儿科
关键词
IgE; 食物过敏; 诊断; 临床评价;
D O I
暂无
中图分类号
R725.9 [小儿全身性疾病];
学科分类号
100202 ;
摘要
目的对IgE介导的食物过敏的诊断流程进行临床评价,探讨高效的食物过敏诊断程序。方法0~6岁患儿88例,以支气管哮喘、过敏性鼻炎、特应性皮炎以及消化道症状为主要临床表现,进行食物过敏原皮肤点刺试验(skinpricktest,SPT),皮肤试验阳性者检测血清特异性IgE(sIgE)、sIgE阳性者进一步进行双盲安慰剂食物激发试验(doubleblindplacebocontrolfoodchallenge,DBPCFC)证实诊断,sIgE阴性者通过DBPCFC建立或排除诊断。结果88例患儿中SPT(+)者25例,其中SPT(+)sIgE(+)者16例,SPT(+)sIgE(-)者9例;前者经DBPCFC进一步证实为食物过敏的有14例;后者通过DBPCFC建立诊断的3例,排除诊断的6例,根据SPT(+)sIgE(+)或SPT(+)sIgE(-)诊断食物过敏的阳性预计值为87.5%,阴性预计值为77.8%。结论皮肤点刺试验结合sIgE检测有较高的食物过敏确诊率,当前两者不一致时,需要通过DBPCFC建立诊断。
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页码:23 / 25
页数:3
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