非酒精性脂肪性肝病与血清尿酸

被引：8

作者：

徐贝贝

王炳元

机构：

[1] 中国医科大学附属第一医院老年消化科

来源：

临床肝胆病杂志 | 2016年 / 32卷 / 03期

关键词：

脂肪肝; 尿酸; 代谢综合征X;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

非酒精性脂肪性肝病(NAFLD)被视为代谢综合征(MS)的肝脏表现,除糖脂代谢紊乱外,血清尿酸(SUA)的水平也左右着NAFLD的进展。叙述了两者相关的最新研究成果,指出无论健康个体或患者的SUA都能够独立预测患者MS、2型糖尿病和心血管疾病的风险,其机制可能是SUA通过诱导活性氧(ROS)增加ROS-硫氧还蛋白相互作用蛋白(TXNIP)表达,进而引发pyrin结构域蛋白3炎症小体激活和白细胞介素的分泌;无论基础或临床研究,使用降低SUA的药物可以抑制TXNIP通路,降低血糖水平,减轻肝细胞ROS、炎症、脂肪变性和纤维化。提示减少SUA可能是NAFLD一个有前途的潜在治疗方法,值得基础和临床的进一步研究。

引用

页码：437 / 441

页数：5

共 19 条

[1]

Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies [J].

Yuan, Huiping ;

Yu, Chenglong ;

Li, Xinghui ;

Sun, Liang ;

Zhu, Xiaoquan ;

Zhao, Chengxiao ;

Zhang, Zheng ;

Yang, Ze .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (11) :4198-4207

[2]

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model [J].

Nakatsu, Yusuke ;

Seno, Yasuyuki ;

Kushiyama, Akifumi ;

Sakoda, Hideyuki ;

Fujishiro, Midori ;

Katasako, Aya ;

Mori, Keiichi ;

Matsunaga, Yasuka ;

Fukushima, Toshiaki ;

Kanaoka, Ryuhei ;

Yamamotoya, Takeshi ;

Kamata, Hideaki ;

Asano, Tomoichiro .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2015, 309 (01) :G42-G51

[3]

Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds [J].

Xu, Chengfu ;

Wan, Xingyong ;

Xu, Lei ;

Weng, Honglei ;

Yan, Ming ;

Miao, Min ;

Sun, Yan ;

Xu, Genyun ;

Dooley, Steven ;

Li, Youming ;

Yu, Chaohui .

JOURNAL OF HEPATOLOGY, 2015, 62 (06) :1412-1419

[4]

Association Between Sex-Specific Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Chinese Adults A Large Population-Based Study [J].

Wu, Sheng-Jie ;

Zhu, Gui-Qi ;

Ye, Bo-Zhi ;

Kong, Fan-Qi ;

Zheng, Zai-Xing ;

Zou, Hai ;

Shi, Ke-Qing ;

Lin, Lu ;

Braddock, Martin ;

Huang, Wei-Jian ;

Chen, Yong-Ping ;

Zheng, Ming-Hua .

MEDICINE, 2015, 94 (17) :e802

[5]

Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients [J].

Nakahara, Takashi ;

Hyogo, Hideyuki ;

Yoneda, Masato ;

Sumida, Yoshio ;

Eguchi, Yuichiro ;

Fujii, Hideki ;

Ono, Masafumi ;

Kawaguchi, Takumi ;

Imajo, Kento ;

Aikata, Hiroshi ;

Tanaka, Saiyu ;

Kanemasa, Kazuyuki ;

Fujimoto, Kazuma ;

Anzai, Keizo ;

Saibara, Toshiji ;

Sata, Michio ;

Nakajima, Atushi ;

Itoh, Yoshito ;

Chayama, Kazuaki ;

Okanoue, Takeshi .

JOURNAL OF GASTROENTEROLOGY, 2014, 49 (11) :1477-1484

[6]

The relationship of serum uric acid with non-alcoholic fatty liver disease [J].

Sertoglu, Erdim ;

Ercin, Cemal Nuri ;

Celebi, Gurkan ;

Gurel, Hasan ;

Kayadibi, Huseyin ;

Genc, Halil ;

Kara, Muammer ;

Dogru, Teoman .

CLINICAL BIOCHEMISTRY, 2014, 47 (06) :383-388

[7]

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats [J].

Wang, Wei ;

Wang, Chuang ;

Ding, Xiao-Qin ;

Pan, Ying ;

Gu, Ting-Ting ;

Wang, Ming-Xing ;

Liu, Yang-Liu ;

Wang, Fu-Meng ;

Wang, Shui-Juan ;

Kong, Ling-Dong .

BRITISH JOURNAL OF PHARMACOLOGY, 2013, 169 (06) :1352-1371

[8]

Association of uric acid levels with components of metabolic syndrome and non-alcoholic fatty liver disease in overweight or obese children and adolescents [J].

Cardoso, Anajas S. ;

Gonzaga, Nathalia C. ;

Medeiros, Carla C. M. ;

de Carvalho, Danielle F. .

JORNAL DE PEDIATRIA, 2013, 89 (04) :412-418

[9]

Metabolic syndrome, diabetes, and hyperuricemia [J].

Li, Changgui ;

Hsieh, Ming-Chia ;

Chang, Shun-Jen .

CURRENT OPINION IN RHEUMATOLOGY, 2013, 25 (02) :210-216

[10]

Association between serum uric acid and nonalcoholic fatty liver disease in the US population.[J].Ming-Hsiung Shih;Mariana Lazo;Su-Hsun Liu;Susanne Bonekamp;Ruben Hernaez;Jeanne M. Clark.Journal of the Formosan Medical Association.2012,

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