基质金属蛋白酶与椎间盘的退变

被引：19

作者：

荆鹏伟

刘泽汉

何旭

公伟勋

王立春

机构：

[1] 哈尔滨医科大学附属第二医院骨科

来源：

中国组织工程研究 | 2012年 / 16卷 / 33期

基金：

黑龙江省自然科学基金;

关键词：

基质金属蛋白酶; 基质金属蛋白酶组织抑制因子; 椎间盘; 退变; 脊柱;

D O I：

暂无

中图分类号：

R681.5 [脊柱及背疾病];

学科分类号：

100220 [骨科学];

摘要：

背景:椎间盘细胞外基质的破坏是椎间盘退变的主要标志,已经证实这与主要基质金属蛋白酶的表达和活性上调有关。然而到目前为止对于基质金属蛋白酶家族的调节几乎没有系统的资料。目的:全面了解基质金属蛋白酶在椎间盘退变中的表达及作用。方法:由第一作者用计算机检索中国生物医学全文数据库(SinoMed:2000/2011)和Medline数据库(2000/2011),检索词分别为"基质金属蛋白酶,基质金属蛋白酶组织抑制因子,椎间盘,退行性变,脊柱"和"matrix metalloproteinases,tissue inhibitor of matrix metalloproteinases,disc,degeneration,intervertebral"。共检索到207篇文章,按纳入和排除标准对文献进行筛选,共纳入31篇文章。回顾收录的基质金属蛋白酶相关综述和论文报告,并分析生物学作用及调节的研究进展。结果与结论:基质金属蛋白酶在椎间盘退变中起着重要作用,已有证据表明基质金属蛋白酶能加速椎间盘细胞外基质的退变进程,并已取得了大量免疫组化证据的支持。

引用

收藏

页码：6243 / 6247

页数：5

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