离子迁移谱及其在药学领域的应用

被引：18

作者：

冯雪

尹利辉

金少鸿

张学博

朱俐

赵瑜

张锐

机构：

[1] 中国食品药品检定研究院

来源：

药物分析杂志 | 2013年 / 33卷 / 07期

关键词：

离子迁移谱(IMS); 气相离子迁移分析; 灵敏度; 药学应用;

D O I：

10.16155/j.0254-1793.2013.07.028

中图分类号：

R917 [药物分析];

学科分类号：

100704 ;

摘要：

离子迁移谱(IMS)是基于大气压下在弱电场中进行气相离子分析的一种检测技术,具有灵敏度高、分析速度快、易于实现便携等特点,应用前景广泛,在药学领域可用于药品质量控制及药品生产过程中洁净度的验证等方面。本文将在介绍离子迁移谱基本原理及其仪器研究进展的基础上,进一步重点阐述离子迁移谱在药学领域的各种应用。

引用

页码：1109 / 1114

页数：6

共 14 条

[1] 离子迁移谱研究进展 [J].

许峰 ;

王海龙 ;

关亚风 .

化学进展, 2005, (03) :514-522

[2] 离子迁移谱检测技术及其应用 [J].

徐淑武 ;

郑健 ;

毕志毅 ;

陈扬骎 .

物理, 2003, (08) :539-542

[3]

Sample-introduction systems coupled to ion-mobility spectrometry equipment for determining compounds present in gaseous, liquid and solid samples[J] . L. Arce,M. Menéndez,R. Garrido-Delgado,M. Valcárcel.Trends in Analytical Chemistry . 2008 (2)

[4] Monitoring copopulated conformational states during protein folding events using Electrospray ionization-ion mobility spectrometry-mass spectrometry [J].

Smith, David P. ;

Giles, Kevin ;

Bateman, Robert H. ;

Radford, Sheena E. ;

Ashcroft, Alison E. .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2007, 18 (12) :2180-2190

[5] Evaluating the utility of ion mobility separation in combination with high-pressure liquid chromatography/mass spectrometry to facilitate detection of trace impurities in formulated drug products [J].

Eckers, Christine ;

Laures, Alice M. -F. ;

Giles, Kevin ;

Major, Hilary ;

Pringle, Steve .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (07) :1255-1263

[6]

Ion Mobility Spectrometry: Principles and Applications[J] . Helko Borsdorf,Gary A. Eiceman.Applied Spectroscopy Reviews . 2006 (4)

[7]

Detection of human metabolites using multi-capillary columns coupled to ion mobility spectrometers[J] . Journal of Chromatography A . 2005 (1)

[8] Modeling the resolution and sensitivity of FAIMS analyses [J].

Shvartsburg, AA ;

Tang, KQ ;

Smith, RD .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2004, 15 (10) :1487-1498

[9]

High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry[J] . Roger Guevremont.Journal of Chromatography A . 2004 (1)

[10] A critical review of ion mobility spectrometry for the detection of explosives and explosive related compounds [J].

Ewing, RG ;

Atkinson, DA ;

Eiceman, GA ;

Ewing, GJ .

TALANTA, 2001, 54 (03) :515-529

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