肝损伤发生机制及其治疗研究进展

被引：30

作者：

邓昕雨

马骁

机构：

[1] 成都中医药大学药学院中药材标准化教育部重点实验室

来源：

中药与临床 | 2022年 / 13卷 / 05期

关键词：

酒精性肝损伤; 化学性肝损伤; 胆汁淤积性肝损伤; 药物性肝损伤;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

肝损伤是指以肝细胞功能障碍和代谢紊乱为特征的一系列危险病理状态，严重时可导致肝衰竭。肝损伤作为各类肝脏疾病发生发展的初级阶段受到了广泛的关注。目前，对于肝损伤的研究仍集中于对致病因素的探讨和治疗药物的挖掘，机制探讨尚不全面。本文以肝损伤的致病机制为切入点，对肝损伤的发生发展及其相关治疗药物的研究进行论述，为肝损伤的治疗提供新的思路。

引用

页码：118 / 123+128 +128

页数：7

共 59 条

[1]

Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology [J].

Wei, Shizhang ;

Ma, Xiao ;

Niu, Ming ;

Wang, Ruilin ;

Yang, Tao ;

Wang, Dan ;

Wen, Jianxia ;

Li, Haotian ;

Zhao, Yanling .

FRONTIERS IN PHARMACOLOGY, 2020, 11

[2]

Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice.[J].Jie Zhao;Cen Xie;Kanglong Wang;Shogo Takahashi;Kristopher W. Krausz;Dasheng Lu;Qiong Wang;Yuhong Luo;Xianqiong Gong;Xiyan Mu;Qiao Wang;Suwen Su;Frank J. Gonzalez.Toxicology Letters.2020,

[3]

Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice [J].

Meng, Xiao ;

Tang, Guo-Yi ;

Liu, Pin-He ;

Zhao, Chan-Juan ;

Liu, Qing ;

Li, Hua-Bin .

WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (37) :5629-5645

[4]

Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review [J].

Ma, Xiao ;

Zhang, Wenwen ;

Jiang, Yinxiao ;

Wen, Jianxia ;

Wei, Shizhang ;

Zhao, Yanling .

FRONTIERS IN PHARMACOLOGY, 2020, 11

[5]

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure [J].

Jaeschke, Hartmut ;

Akakpo, Jephte Y. ;

Umbaugh, David S. ;

Ramachandran, Anup .

TOXICOLOGICAL SCIENCES, 2020, 174 (02) :159-167

[6]

The Role of Complement in Liver Injury, Regeneration, and Transplantation [J].

Thorgersen, Ebbe Billmann ;

Barratt-Due, Andreas ;

Haugaa, Hakon ;

Harboe, Morten ;

Pischke, Soren Erik ;

Nilsson, Per H. ;

Mollnes, Tom Eirik .

HEPATOLOGY, 2019, 70 (02) :725-736

[7]

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China [J].

Shen, Tao ;

Liu, Yingxia ;

Shang, Jia ;

Xie, Qing ;

Li, Jun ;

Yan, Ming ;

Xu, Jianming ;

Niu, Junqi ;

Liu, Jiajun ;

Watkins, Paul B. ;

Aithal, Guruprasad P. ;

Andrade, Raul J. ;

Dou, Xiaoguang ;

Yao, Lvfeng ;

Lv, Fangfang ;

Wang, Qi ;

Li, Yongguo ;

Zhou, Xinmin ;

Zhang, Yuexin ;

Zong, Peilan ;

Wan, Bin ;

Zou, Zhengsheng ;

Yang, Dongliang ;

Nie, Yuqiang ;

Li, Dongliang ;

Wang, Yuya ;

Han, Xi'an ;

Zhuang, Hui ;

Mao, Yimin ;

Chen, Chengwei .

GASTROENTEROLOGY, 2019, 156 (08) :2230-+

[8]

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges [J].

Liu, Yi ;

Wang, Wenping ;

Sun, Mingyi ;

Ma, Baorui ;

Pang, Linnuo ;

Du, Yuanyuan ;

Dong, Xiaoxv ;

Yin, Xingbin ;

Ni, Jian .

FRONTIERS IN PHARMACOLOGY, 2019, 10

[9]

Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation; Oxidative Stress; and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling.[J].Chien-Ta Wu;Jeng-Shyan Deng;Wen-Chin Huang;Po-Chou Shieh;Mei-Ing Chung;Guan-Jhong Huang.Oxidative Medicine and Cellular Longevity.2019,

[10]

Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats [J].

Ma, Xiao ;

Wen, Jian-Xia ;

Gao, Si-Jia ;

He, Xuan ;

Li, Peng-Yan ;

Yang, Yu-Xue ;

Wei, Shi-zhang ;

Zhao, Yan-Ling ;

Xiao, Xiao-He .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2018, 70 (12) :1675-1687

← 1 2 3 4 5 6 →