Ox-LDL促进Aβ产生的实验研究及其临床意义附视频

被引：1

作者：

刘江红

黎健

许贤豪

张华

国红

王红

殷剑

张星虎

乔立艳

魏雪飞

矫毓娟

文诗广

侯世芳

耿莹

机构：

[1] 中国协和医科大学

[2] 卫生部北京医院

[3] 北京天坛医院神经内科

来源：

中国神经免疫学和神经病学杂志 | 2003年 / 01期

关键词：

细胞培养; 动脉粥样硬化; 老年性痴呆;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

目的　探讨氧化型低密度脂蛋白 (Ox-LDL)能否促进 β淀粉样蛋白 (Aβ)产生。方法　应用体外细胞培养和免疫荧光流式细胞术以及反转录 PCR方法 ,检测经 Ox-LDL处理的平滑肌细胞 (SMC) Aβ的产生及β淀粉样蛋白前体 (APP)基因水平。结果　经 Ox-LDL 处理的 SMC Aβ1 -40较对照组明显增高 ,分别为 88.3 0 %和2 .1 6% ;Aβ1 -42也较对照组明显增高 ,分别为 95 .3 0 %和 2 .5 1 %。结论　Ox-LDL促进 Aβ产生。

引用

页码：35 / 38

页数：4

共 9 条

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